APOE4 Supplement Protocol
Every APOE4 carrier should start here. These four supplements address the core biological vulnerabilities of the APOE4 genotype — and they're the foundation Jess builds every personalized protocol on top of.
Start Here
These four supplements are the non-negotiables — the baseline every APOE4 carrier should have in place before adding anything else. Click any card to expand the science, dosing, and Jess's personal note.
Beyond the Basics
The foundation stack gets you started. The specialty stack is where we get specific — targeting your individual APOE4 expression, vascular health, neuroinflammation levels, and mitochondrial function. This is what Jess builds with you personally.
Lysoveta Omega-3 Protocol
Specific dosing for APOE4 vascular optimization
Vascular Support Stack
L-Citrulline + targeted compounds for cerebrovascular function
Neuroinflammation Protocol
Curcumin formulation + synergistic compounds
Mitochondrial Support
ALCAR + targeted energy compounds for APOE4 neurons
Senolytic Protocol
Fisetin-based cellular cleanup strategy
Neuroprotective Compounds
Emerging evidence-based additions for APOE4 carriers
Your Personalized Protocol
Your APOE4 expression, vascular health, homocysteine levels, and lifestyle all determine which compounds you need — and at what doses. Jess builds your personal protocol in a free 15-minute evaluation. No obligation. No overwhelm. Just clarity.
Book Your Free 15-Minute EvaluationFree. No sales pitch. Just Jess, your results, and a plan.
Why I recommend what I recommend: Every supplement on this page is something I personally use or have vetted with my clients over 30 years of dementia care. I include honest caveats, explain the APOE4 science behind each choice, and disclose all affiliate relationships. Some links earn a small commission at no extra cost to you — this is how I keep this resource free. Read my full recommendation philosophy →